Translational research, which is a marriage between basic science and clinical investigation, is being carried out in our program with the goal of making significant contributions to the development of novel molecularly targeted treatments for retinal disease.
The aim of our research program is to use genomics in a multi-faceted and interdisciplinary, systems-oriented approach to understand the molecular basis of common blinding retinal conditions, such as diabetic retinopathy, age-related macular degeneration and retinitis pigmentosa.
Vision loss is the most feared disability, and the anticipated numbers of affected individuals with retinal disease over the coming years is staggering. Numerous ophthalmologic conditions have been identified and exquisitely described, however, the basic underlying pathogenic mechanisms remain to be determined.
Using cell lines, patient samples, and donor eyes we are conducting genome-wide association studies; cellular screening experiments with small molecules; genome-wide RNA interference; and DNA expression analyses in order to identify the molecular mechanisms that contribute to retinal disease development.
University of Chicago 5841 S. Maryland Ave.,Abbott 302 (MC2114) Chicago, IL 60637
Phone: 773-702-5305 FAX: 773-702-4442